Zacharia T. Laagye, PhD
Department of Biology,
College of Education,
Katsina-Ala, Benue State
This study investigated the effect of orally administered Goko herbal cleansing mixture on the haematological parameters of 30 adult female wistar rats that weighed between 160g to 180g. The rats were randomly selected into three groups; group A (control) and group B and C (experimental groups) having 10 rats each. The control group received no treatment whereas the rats in experimental groups B and C were treated with 100 ml and 200 ml of the mixture given in divided does of 10 ml and 20 ml respectively for 30 days. At the end of the treatment period the rats were sacrificed, blood samples taken and hematological parameters determined. The mean red blood cell count (RBC) and haematocrit level (HCT) of rats in the experimental groups significantly decreased compared to those in the control group (p<0.05). The mean haemoglobin concentration (HGB), mean corpuscular concentration (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) of the experimental groups were significantly higher than the control group. Similarly, the mean white blood cell (WBC) count of the experimental groups increased significantly compared to the control group. However, no significant differences were observed between the granulocytes, monocytes and lymphocytes of the experimental and control groups. The mean platelet counts of the experimental groups were significantly higher compared to the control group.
KEY WORDS: HAEMATOLOGICAL PARAMETERS, GOKO HERBAL MEDICINE, WISTAR RATS